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Huntington Disease

SCT protects against neuronal loss and recovers functional deficit in Huntington disease

Published in Blood Weekly, July 13th, 2006

Stem cell transplantation protects against neuronal loss and recovers functional deficit in Huntington's disease.

According to a recent review from South Korea, "Huntington's disease (HD) is a fatal, genetically based late-onset neurodegenerative disorder in which a loss of neostriatal neurons is a main characteristic.

"The CAG trinucleotide repeat expansion encoding polyglutamine tract induces progressive deficits in intra- and intercellular signaling, and subsequent clinical signs developed with aging process."

"CAG-induced neurodegeneration and disease-onset shows aging-dependent pattern. Proposed mechanism of neurodegeneration...

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