Published in Blood Weekly, July 13th, 2006
"Mathematical modeling forms a key component of systems biology, offering insights that complement and stimulate experimental studies. In this review, we illustrate the role of theoretical models in elucidating the mechanisms involved in normal intestinal crypt dynamics and colorectal cancer," scientists in England report.
According to the authors, "We discuss a range of modeling approaches, including models that describe cell proliferation, migration, differentiation, crypt fission, genetic instability, APC inactivation and tumor heterogeneity.
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