Multiple Myeloma
Inhibitory anti-FGFR3 antibody is cytotoxic to t(4;14) multiple myeloma cells
Published in Blood Weekly, July 20th, 2006
According to scientists in Canada and Israel, "The association of fibroblast growth factor receptor 3 (FGFR3) expression with t(4;14) multiple myeloma (MM) and the demonstration of the transforming potential of this receptor tyrosine kinase (RTK) make it a particularly attractive target for drug development. We report a novel and highly specific anti-FGFR3-neutralizing antibody (PRO-001)."
"PRO-001 binds to FGFR3 expressed on transformed cells and inhibits FGFR3 autophosphorylation and downstream signaling," said Suzanne Trudel and collaborators at the...
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Source: Blood Weekly (2006-07-20)
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