Apoptosis

Leukemia cell-induced apoptosis is sensitized by MEK1 inhibition

Published in Blood Weekly, July 27th, 2006

A study from Italy has reported that MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide (ATO)-induced apoptosis.

"We found that MEK1 inhibitor PD184352 strikingly increased apoptosis induced by ATO in 21 of 25 patients with primary acute myelogenous leukemia (AML). Isobologram analysis confirmed the synergistic (13 of 25 patients) or additive (8 of 25 patients) nature of this interaction," wrote P. Lunghi and colleagues, University of Parma.

"Moreover, we demonstrated that the p53-related gene p73 is a molecular target of the combined treatment in AML blasts. Indeed, ATO modulates the expression of the p73 gene by...

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Source: Blood Weekly (2006-07-27)

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