Published in Blood Weekly, July 27th, 2006
"We found that MEK1 inhibitor PD184352 strikingly increased apoptosis induced by ATO in 21 of 25 patients with primary acute myelogenous leukemia (AML). Isobologram analysis confirmed the synergistic (13 of 25 patients) or additive (8 of 25 patients) nature of this interaction," wrote P. Lunghi and colleagues, University of Parma.
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