Stem Cell Research
Pten dependence distinguishes hematopoietic stem cells from leukemia-initiating cells
Published in Blood Weekly, August 3rd, 2006
"Recent advances have highlighted extensive phenotypic and functional similarities between normal stem cells and cancer stem cells. This raises the question of whether disease therapies can be developed that eliminate cancer stem cells without eliminating normal stem cells," researchers in the United States report.
According to O.H. Yilmaz and colleagues, University Michigan, "Here we address this issue by conditionally deleting the Pten tumor suppressor gene in adult hematopoietic cells. This led to myeloproliferative disease within days and...
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Source: Blood Weekly (2006-08-03)
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