Published in Blood Weekly, August 17th, 2006
According to a study from Japan, "The effect of interleukin-18 (IL-18) on metastasis of highly metastatic LM8 mouse osteosarcoma cells was investigated using nude mice treated with antiasialo GM1 serum to exclude antitumor actions of IL-18 through activation of T and natural killer cells."
Y. Nakamura and colleagues at Hyogo Medical University reported, "Injection of LM8 cells which do not express IL-18 receptor beta into a tail vain resulted in the formation of pulmonary and hepatic metastatic foci.
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