MALT Lymphoma
MALT lymphoma-associated translocations not linked to nuclear BCL-10 expression
Published in Blood Weekly, August 24th, 2006
According to recent research from the United States, "BCL-10 is expressed in the cytoplasm of normal germinal center and marginal zone B-cells and is involved in lymphocyte development and activation. Aberrant nuclear expression of BCL-10 occurs in a subset of extranodal marginal zone B-cell lymphomas (MALT lymphomas), primarily those with the t(1; 14)(p22;q32) or t(11;18)(q21;q21)."
"Little is known about BCL-10 expression in lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia (LPL/WM). We assessed for BCL-10 in 51 bone marrow (BM)...
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Source: Blood Weekly (2006-08-24)
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