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Embryonic Stem Cell Research

Transcription organization conserved during embryonic stem cell differentiation

Published in Blood Weekly, September 7th, 2006

Transcription organization is conserved during embryonic stem cell differentiation.

According to a recently published study from England, "Although we have detailed information on the alterations occurring in steady-state levels of all cellular mRNAs during differentiation, we still know little about more global changes.

"Therefore, we investigated the numbers of molecules of RNA polymerase II that are active- and the way those molecules are organized-as two mouse cells (aneuploid F9 teratocarcinoma, and euploid and totipotent embryonic stem cells) differentiate into parietal endoderm."

"Quantitative immunoblotting shows the...

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