Hematopoiesis in liver, spleen, and bone marrow overlap perinatally

According to recent research from Japan, "The transition of fetal hematopoietic sites in mice was examined histologically from 12.5-day embryos (E12.5) until 10 days of age (D10), and the expression of the adhesive molecules VCAM-1 and fibronectin was examined immunohistologically. Erythropoiesis occurred in the liver (E12.5-18.5), spleen (E18.5-D4) and bone marrow (D6-10), in that sequence."

"Even at D10," wrote T. Tada and colleagues at Nagoya University, "some erythropoiesis occurred in the liver, and more so in the spleen, although the active hematopoietic site was the bone...

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