Published in Blood Weekly, September 14th, 2006
"It is well known that the implantation of bone marrow mononuclear cells (BM-MNCs) into ischemic hearts can induce angiogenesis and improve cardiac function after myocardial infarction, but the precise mechanisms of these actions are unclear. We hypothesize that the cytokines produced by BM-MNCs play a key role in this cell-based therapy," investigators in Japan report.
"BM-MNCs from rats were cultured under normoxic or hypoxic (1% O2 ) conditions for 24 h, and then supernatants were collected for study. Enzyme-linked immunosorbent assay and Western...
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