Blood Banking
Platelet binding and phagocytosis by macrophages is reduced using metabolic arrest
Published in Blood Weekly, September 28th, 2006
"Earlier it was reported that metabolic arrest followed by incubation at 4 degrees C reduces the PLT storage defect. Here it is reported that this treatment also reduces binding and phagocytosis by macrophages," scientists writing in the journal Transfusion report.
"Phagocytosis of mepacrine-labeled PLTs by macrophages changes the latter into bright fluorescent particles easily detected by fluorescence-activated cell sorting. In combination with conventional binding analysis it was found that binding to phorbol 12-myristate...
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Source: Blood Weekly (2006-09-28)
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