Drug Development
13-amino costunolide derivatives synthesized and evaluated as anticancer agents
Published in Blood Weekly, September 28th, 2006
According to recent research from India, "A number of costunolide derivatives (4a-p) have been synthesized and evaluated for their in vitro cytotoxicity against 8 tumor and a non-tumor cell lines. Compound 4d showed around 2-fold better cytotoxicity against SW-620 (colon) cell line with improved safety index than costunolide (1)."
"While compounds 4e, 4g, and 4p have shown around 2- to 3-fold better cytotoxicity against MIAPaCa2 (pancreas), K-562 (leukemia) and PA-1 (ovary) cell lines as well as better safety index in comparison to costunolide...
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Source: Blood Weekly (2006-09-28)
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