Blood Banking

Several factors affect bone marrow volume reduction and red blood cell depletion prior to transplant

Published in Blood Weekly, September 28th, 2006

Several factors affect bone marrow volume reduction and red blood cell depletion prior to transplantation.

According to recent research published in the journal Bone Marrow Transplantation, "The COBE Spectra is used to volume/red blood cell (RBC) deplete BM before transplantation or cryopreservation.

"We have audited our results to identify the effect of transit time, refrigerated storage, age and cellular composition on mononuclear cells (MNC) and CD34+ cell recoveries, volume/RBC depletion and neutrophil engraftment."

"In total, 88 consecutive collections from autologous (n=25) and allogeneic (n=63) donors were included....

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Source: Blood Weekly (2006-09-28)

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