Leukemia
Leukemia linked to gain-of-function mutations of nucleophosmin
Published in Blood Weekly, September 28th, 2006
"NPM is a nucleus-cytoplasmic shuttling protein that is implicated in centrosome duplication, cell cycle progression and stress response. At the steady state, NPM localizes mainly in the nucleolus, where it forms a complex with different cellular proteins," investigators in Italy reported.
"One-third of AML are characterized by aberrant cytoplasmic localization of NPM, due to mutations within its last coding exon (exon 12) that cause a frameshift and the formation of novel C-termini," explained A.R. Mariano and colleagues, European Institute of Oncology. "We...
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Source: Blood Weekly (2006-09-28)
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