Stem Cell Research

Aggrecan constitutively expressed by MSC and type X collagen expressed as an early event

Published in Blood Weekly, October 5th, 2006

Aggrecan is constitutively expressed by mesenchymal stem cells and type X collagen is expressed as an early event.

"The study was initially designed to differentiate human bone marrow-derived mesenchymal stem cells (MSC) into chondrocyte-like cells, for use in tissue engineering.

"We cultured MSCs in defined chondrogenic medium as pellet cultures supplemented with transforming growth factor (TGF)-beta 1 or -beta 3 and dexamethazone, as they are commonly used to promote in vitro chondrogenesis," scientists in Canada report.

According to F. Mwale and colleagues at McGill University in Montreal, "Markers of chondrogenesis used were...

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Source: Blood Weekly (2006-10-05)

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