Blood Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Blood Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Apoptosis
Pinusolide evaluated for its antileukemic potential
October 5th, 2006
Pinusolide was evaluated for its antileukemic potential. "Pinusolide (1), a known platelet-activating factor (PAF) receptor binding antagonist, was synthesized from lambertianic acid (2), a labdane-type diterpene readily accessible in multigram quantities from the Siberian pine tree," scientists in Russia reported. "It was shown that 1 not only decreases the proliferation activity of tumor cells at relatively low concentrations but specifically induces apoptosis at 100 PM via the mitochondrial pathway in the Burkitt lymphoma cell line BJAB," explained E.E. Shults and colleagues, Russian Academy of Science. The researchers...
Source: Blood Weekly (2006-10-05)
|
