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Cancer Pharmacogenomics
Genomics used to predict response to chemotherapy
October 5th, 2006
Pharmacogenomics may be used to predict response to chemotherapy. According to a recent report from England, "With large and locally advanced breast cancer (LLABC) present with a therapeutic challenge and undergo multimodality treatment. Many such patients receive neoadjuvant chemotherapy (NAC) prior to surgery." "However, a number of these patients do not respond well to NAC and only a percentage (usually less than 30%) obtains a complete or optimal response. A range of mechanisms are believed to be involved in this chemoresistance, including ATP binding cassette (ABC) transporter overexpression, dysregulation of apoptosis and possibly increased...
Source: Blood Weekly (2006-10-05)
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