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Cell Transplants
Reduced survival after HLA-identical SCT may be caused by pre-existing viral infections
October 5th, 2006
Reduced survival after HLA-identical stem cell transplant may be caused by pre-existing viral infections. According to a study from France, "Major histocompatibility complex class II deficiency, a rare autosomal recessive primary immunodeficiency, is caused by the defective expression of human leucocyte antigen (HLA) class II molecules due to mutated trans-acting elements of any one of four regulatory genes (CIITA, RFXANK, RFX5, RFXAP). "The impaired CD4 T-cell differentiation and antigen presentation in the periphery results in a severe defect of cellular and humoral response consistent with severe recurrent infections, leading to a poor...
Source: Blood Weekly (2006-10-05)
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