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Colon Cancer
IL-11-receptor alpha-protein expression decreased in colon carcinoma
October 5th, 2006
Interleukin-11-receptor alpha-protein expression is decreased in epithelial cells from colon carcinomas and adenomas. "Interleukin-11 (IL-11) has been evaluated as an anti-inflammatory and mucosa-protective therapeutic agent in inflammatory bowel diseases (IBDs). Activity of IL-11 requires binding to the alpha receptor subunit (IL-11R alpha) that provides ligand specificity," investigators in Germany report. According to the authors, "Recently, we showed that in the intestinal mucosa, IL-11R alpha is mainly present on epithelial cells mediating antiapoptotic effects. The aim of this study was to investigate the expression profiling of IL-11R alpha...
Source: Blood Weekly (2006-10-05)
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