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Corneal Graft



Corneal graft rejection risk is lowered in rabbits treated with rapamycin implants



October 5th, 2006

Corneal graft rejection risk is lowered in rabbits treated with rapamycin implants.

Scientists in the People's Republic of China conducted a study "to evaluate the immunosuppressive and antiangiogenic activities of an intraocular rapamycin (RAPA) drug delivery system (DDS) in a rabbit model of high-risk penetrating keratoplasty. Forty New Zealand White rabbits with corneal neo-vascularization underwent allograft cornea transplantation and were randomly divided into four groups: a control group, a glycolide-co-lactide-co-caprolactone copolymer (PGLC)-implanted group, a RAPA eye drop group, and a RAPA-PGLC DDS-implanted group."

"Graft survival, corneal...


Source: Blood Weekly (2006-10-05)

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