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Hematopoiesis
Cytokines induce megakaryocytopoiesis and thrombopoiesis from X-irradiated stem cells
October 5th, 2006
Cytokines induce megakaryocytopoiesis and thrombopoiesis from X-irradiated hematopoietic stem cells. According to recent research from Japan, "In the present study, we investigated whether X-irradiated hematopoietic stem cells can be induced to undergo megakaryocytopoiesis and thrombopoiesis in vitro using cytokine combinations that have been demonstrated to be effective for conferring increased survival on irradiated human CD34+ megakaryocytic progenitor cells (colony-forming unit megakaryocytes; CFU-Meg), such as thrombopoietin (TPO), interleukin 3 (IL3), stem cell factor and FLT3 ligand." "Culture of nonirradiated CD34+ cells in serum-free medium...
Source: Blood Weekly (2006-10-05)
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