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Alzheimer Disease
Selective Alzheimer Disease Indicator-1 gene abundantly expressed by stem cells
October 5th, 2006
Seladin-1 antiapoptotic gene is abundantly expressed by stem cells. "Seladin-1 (SELective Alzheimer's Disease INdicator-1) is an antiapoptotic gene, which is downregulated in brain regions affected by Alzheimer's disease (AD). In addition, seladin-1 catalyzes the conversion of desmosterol into cholesterol," scientists writing in the journal Experimental Cell Research report. According to S. Benvenuti and colleagues at the University of Florence, "Disruption of cholesterol homeostasis in neurons may increase cell susceptibility to toxic agents. "Because the hippocampus and the subventricular zone, which are affected in AD,...
Source: Blood Weekly (2006-10-05)
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