Published in Blood Weekly, October 12th, 2006
"The proteasome inhibitors are a new class of antitumor agents. These inhibitors cause the accumulation of many proteins in the cell with the induction of apoptosis including TRAIL death receptors DR4 and DR5, but the role of the TRAIL apoptotic pathway in proteasome inhibitor cytotoxicity is unknown," wrote A.F. Kabore and colleagues, University of Manitoba.
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