Cancer Gene Therapy

Gene therapy model reveals unique risk factors for insertional mutagenesis

Published in Blood Weekly, October 12th, 2006

A study from the United States has reported on unique risk factors for insertional mutagenesis in a mouse model of X-linked severe combined immunodeficiency (SCID) (XSCID) gene therapy.

"Although gene therapy can cure patients with SCID syndromes, the clinical occurrence of T cell malignancies due to insertional mutagenesis has raised concerns about the safety of gene therapy," wrote Y. Shou and colleagues, St. Jude Children's Hospital & Research Center.

"Several key questions have remained unanswered: (i) are there unique risk factors for X-linked SCID (XSCID) gene therapy that increase the risk of insertional mutagenesis; (ii) what other genetic...

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Source: Blood Weekly (2006-10-12)

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