Stem Cell Research

Identified peptide selectively binds to embryonic carcinoma stem cells

Published in Blood Weekly, October 12th, 2006

A peptide has been identified that selectively binds to embryonic carcinoma stem cells.

"The P19 cell is a pluripotent stem cell of murine teratocarcinoma. When treated with retinoic acid, P19 cells can be differentiated along a neural cell lineage in culture," scientists in Japan report.

According to Y. Morita and colleagues at Kinki University in Fukuoka, "To isolate peptides that bind to the stem cell, we employed a phage display technology with undifferentiated P19 cells as the target.

"To reduce nonspecific binding of phages to the cell surface, the phage libraries were preadsorbed to the differentiated P19 cells before each...

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Source: Blood Weekly (2006-10-12)

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