Drug Development
Calpain proposed as novel target for cancer therapy
Published in Blood Weekly, October 19th, 2006
"Calpain is a class of Ca2+-dependent cysteine proteases and has been suggested to be involved in several important signaling cascades. A series of novel aldehyde calpain inhibitors identified in our laboratory were more potent and specific than commercially available calpain inhibitors, and were used to assess the involvement of calpain in cancer," scientists in the United States reported.
"Our inhibitors demonstrated potent anti-proliferative activity in four cancer cell lines (PC-3, HeLa, Jurkat and Daudi) with IC50 's ranging from 2 to >30 mcM. A non-cancer cell...
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Source: Blood Weekly (2006-10-19)
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