Stem Cell Research

E6/E7 oncogenes increase and tumor suppressors decrease proportion of neural progenitors

Published in Blood Weekly, October 19th, 2006

E6/E7 oncogenes increase and tumor suppressors decrease the proportion of self-renewing neural progenitor cells.

According to recent research published in the journal Oncogene, "Many if not most tissues need a controlled number of stem cells to maintain normal function. Cancer can be seen as a process of disturbed tissue homeostasis, in which too many cells have or acquire too primitive identity.

"Here we measured how oncogenes and tumor suppressors affect the differentiation capacity, proportion and characteristics of progenitor cells in a model tissue."

"Neural progenitor cells (NPCs) were exposed to human papilloma virus...

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Source: Blood Weekly (2006-10-19)

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