Leukemia

New data from Japan, Spain and the United States lluminates research in leukemia

Published in Blood Weekly, November 9th, 2006

Data on leukemia are outlined in reports from Japan, Spain and the United States.

Study 1: Novel therapies that target Rap1 could potentially be used to treat leukemias caused by BCR/ABL.

"The Ras family small GTPase Rap1 is activated by hematopoietic cytokines, such as interleukin (IL)-3, to induce beta 1 integrin-mediated cell adhesion or by the BCR/ABL fusion tyrosine kinase to stimulate the MEK/Erk signaling pathway. Here, we demonstrate that the abrogation of Rap1 activation by SPA-1, a Rap1-specific GAP, inhibits activation of B-Raf, MEK, Erk, and Akt in a murine hematopoietic cell line, Ton.B210, stimulated with IL-3 or inducibly expressing...

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Source: Blood Weekly (2006-11-09)

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