Stem Cell Research

NUMB inhibits Notch signaling in progenitor cells to induce differentiation

Published in Blood Weekly, November 9th, 2006

NUMB inhibits Notch signaling in progenitor cells to induce differentiation.

According to a recently published study in the journal International Journal of Molecular Medicine, "Notch, FGF and WNT signaling pathways cross-talk during embryogenesis, tissue regeneration and carcinogenesis.

"Notch-ligand binding to Notch receptors leads to the cleavage of Notch receptors and the following nuclear translocation of Notch intracellular domain (NICD) to induce transcriptional activation of Notch target genes."

"Notch signaling inhibitors, NUMB and NUMB-like (NUMBL), are docking proteins with PTB domain. We searched for the...

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Source: Blood Weekly (2006-11-09)

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