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Cardiovascular Research

LVAD prolonged support-associated changes in collagen composition are studied

Published in Blood Weekly, November 16th, 2006

Reverse remodeling of the myocardial extracellular matrix (ECM) after prolonged left ventricular assist device (LVAD) support follows a biphasic pattern.

According to recent research from the Netherlands, "Collagens are important components of the ECM. Alterations in collagen structure and composition can lead to end-stage heart failure. LVADs are frequently used as a bridge to heart transplantation (HTx). In this study, we analyzed changes in composition of the collagens as well as the synthesis or degradation of these collagens after prolonged LVAD support."

A.H. Bruggink and colleagues, University of Utrecht, wrote, "The ECM volume was quantified...

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