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Critical Care Medicine

Response to recombinant factor VIIa predicted patients with severe hemorrhage

Published in Blood Weekly, November 16th, 2006

A study from the United Kingdom has documented the prediction of response to recombinant factor VIIa (rFVIIa) in non-hemophiliac patients with severe haemorrhage.

"Despite increasing use of rFVIIa in non-haemophiliac patients, it is unclear when rFVIIa might be effective. A single centre review of consecutive non-haemophiliac patients receiving rFVIIa for the management of severe haemorrhage," wrote K.M. Bowles and colleagues, Addenbrookes Hospital.

"Treatments with rFVIIa were at a dose of 90 mcg kg-1 repeated at three hourly intervals at the clinicians' discretion. Eighteen patients received rFVIIa. Six patients survived to discharge and...

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