Pancreatic Cancer Treatment
p53-derived peptide blocks pancreatic cancer cell growth
Published in Blood Weekly, November 16th, 2006
According to recent research from the United States, "PNC-28 is a p53 peptide from its mdm-2-binding domain (residues 17-26), which contains the penetratin sequence enabling cell penetration on its carboxyl terminal end.
"We have found that this peptide induces necrosis, but not apoptosis, of a variety of human tumor cell lines, including several with homozygous deletion of p53, and a ras-transformed rat acinar pancreatic carcinoma cell line, BMRPA1."
"Tuc3. On the other hand," wrote J. Michl and colleagues at State University of New York Downstate Medical Center in...
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Source: Blood Weekly (2006-11-16)
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