Bone Research

A novel vascular targeting agent prevents the development of bone tumors in mice

Published in Blood Weekly, December 7th, 2006

A novel vascular targeting agent completely prevented the development of bone tumors in 50% of the mice tested in a preclinical study, providing early evidence that it could treat, or thwart, growth of tumors in bone, a common destination for a number of cancers when they start to spread.

Researchers at The University of Texas M. D. Anderson Cancer Center reported in the journal Cancer Research that this "Trojan Horse" agent, VEGF121/rGel, stopped specialized cells within the bone from chewing up other bone material to make room for the implanted tumor to grow.

Although this study tested the ability of VEGF121/rGel to halt the growth of human...

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Source: Blood Weekly (2006-12-07)

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