Sepsis
New sepsis research from University of Amsterdam outlined
Published in Blood Weekly, March 8th, 2007
A new study, "Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia," is now available. "Plasminogen activator inhibitor type-1 (PAI-1) levels are consistently elevated in patients with severe pneumonia and sepsis and highly predictive for an unfavorable outcome. In addition, pneumonia is associated with strongly elevated PAI-1 levels in the pulmonary compartment," investigators in Netherlands report.
"However, whether PAI-1 causally affects antibacterial host defense in vivo remains unknown. We report here that pneumonia caused by the common respiratory pathogen Klebsiella pneumoniae is associated with local production of...
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Source: Blood Weekly (2007-03-08)
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