Ischemia Therapy
Studies from Hannover Medical School provide new data on ischemia therapy
Published in Blood Weekly, May 3rd, 2007
A new study, "Statins attenuate ischemia-reperfusion injury by inducing heme oxygenase-1 in infiltrating macrophages," is now available. "Statins induce heme oxygenase-1 (HO-1) in several cell types, such as vascular smooth muscle cells, endothelial cells, and macrophages. The present study assessed the role of statin-induced HO-1 up-regulation on circulating monocytes/macrophages and their contribution in preventing renal ischemia-reperfusion (IR) injury in a rat model," scientists in Hannover, Germany report.
"Cerivastatin was administered via gavage (0.5 mg/kg) for 3 days before IR injury; controls received vehicle. Statin pretreatment reduced renal damage and...
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Source: Blood Weekly (2007-05-03)
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