Sepsis Physiology
Study data from Washington University, Department of Anesthesiology update understanding of sepsis physiology
Published in Blood Weekly, May 17th, 2007
Scientists discuss in "Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo" new findings in sepsis. According to recent research from the United States, "We hypothesized that spleen microarray gene expression profiles analyzed with contemporary pathway analysis software would provide molecular pathways of interest and target genes that might help explain the effect of bcl-2 on improving survival during sepsis. Two mouse models of sepsis, cecal ligation and puncture and tracheal instillation of Pseudomonas aeruginosa, were tested in both wild-type mice and mice that overexpress bcl-2."
"Whole spleens were obtained 6 h...
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Source: Blood Weekly (2007-05-17)
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