Leukemia Cell Biology
New leukemia cell biology study findings have been reported by scientists at Karolinska Institut, Division of Molecular Toxicology
Published in Blood Weekly, May 31st, 2007
A report, "Smac-mediated sensitization of human B-lymphoma cells to staurosporine- and lactacystin-triggered apoptosis is apoptosome-dependent," is newly published data in Leukemia. According to a study from Stockholm, Sweden, "Second mitochondrial activator of caspase (Smac)-derived peptides have previously been shown to facilitate apoptosis of various types of cancer cells. However, it remains unclear whether the effects of such Smac agonists are dependent on apoptotic protease-activating factor-1 (Apaf-1), a key component of the apoptosome."
"Here, we explored the role of Apaf-1 through overexpression of this protein in the B-lymphoma cell line Raji that is...
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Source: Blood Weekly (2007-05-31)
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