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Cell Biology

New findings from Lindsley F. Kimball Research Institute in the area of cell biology described

Published in Blood Weekly, May 31st, 2007

Researchers detail in "Jedi--a novel transmembrane protein expressed in early hematopoietic cells," new data in cell biology. "Self-renewal and differentiation of hematopoietic stem and progenitor cells are defined by the ensembles of genes expressed by these cells. Here we report identification of a novel gene named Jedi, which is expressed predominantly in short-and long-term repopulating stem cells when compared to more mature bone marrow progenitors," researchers in the United States report.

"Jedi mRNA encodes a transmembrane protein that contains multiple EGF-like repeats. Jedi and two earlier reported proteins, MEGF10 and MEGF11, share a substantial homology and...

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