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Lymphoma

Scientists at National Institute of Radiological Science discuss research in lymphoma

Published in Blood Weekly, June 7th, 2007

A new study, "Ikaros is a mutational target for lymphomagenesis in Mlh1-deficient mice," is now available. According to recent research published in the journal Oncogene, "Deficiencies in DNA mismatch repair (MMR) result in replication errors within key tumor suppressor genes or oncogenes, and cause hereditary nonpolyposis colorectal cancer (HNPCC). Hematological malignancy with microsatellite instability is also associated with defective MMR, but little is known about the target genes for MMR."

"Here we identified Ikaros, a master transcription factor of lymphoid lineage commitment and differentiation, as a mutational target in spontaneous and radiation-induced...

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