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Ischemia

Research from Netherlands Institute for Neuroscience broadens understanding of ischemia

Published in Blood Weekly, June 14th, 2007

Research findings, "GAP-43 expression is upregulated in retinal ganglion cells after ischemia/reperfusion-induced damage," are discussed in a new report. "In response to injury, the adult mammalian retina shows signs of structural remodeling, possibly in an attempt to preserve or regain some of its functional neural connections. In order to study the mechanisms involved in injury-induced plasticity, we have studied changes in growth associated protein 43 (GAP-43) after retinal ischemia/reperfusion in the rat," scientists in Netherlands report.

"GAP-43 is a marker for neuronal remodeling and is involved in synapse formation. Ischemic injury of the rat retina was induced...

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