New leukemia study findings have been reported by researchers at Aichi Cancer Center Hospital

Current study results from the report, "Development-dependent expression of cyclin D3 in precursor T-cell lymphoblastic leukemia/lymphoma," have been published. "In contrast to the clear oncogenic role of cyclins D1 and D2, cyclin D3 is suggested to have a role in the initiation and/or maintenance of differentiation in a lineage-associated manner in addition to its basic role in proliferation. Recently, it has been reported that in cyclin D3-deficient mice, normal expansion of T lymphocytes is impaired because of maturation arrest at the double-negative thymocyte stage, suggesting a crucial role for cyclin D3 in early T-cell development," scientists in Nagoya, Japan report.

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