Mantle Cell Lymphoma Therapy
Reports from University of Barcelona, Department of Pathology advance knowledge in mantle cell lymphoma therapy
Published in Blood Weekly, June 21st, 2007
Research findings, "The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak," are discussed in a new report. "Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma resistant to conventional chemotherapy. The Bcl-2 pathway is deregulated in these tumors and may represent an interesting target for new therapeutic strategies," scientists in Spain report.
"The new small-molecule pan-Bcl-2 inhibitor GX15-070 mimics BH3-only proteins by binding to multiple antiapoptotic Bcl-2 members. Here we show that GX15-070 induced apoptosis in vitro in MCL cell lines and primary cells from patients with MCL by...
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Source: Blood Weekly (2007-06-21)
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