Gaucher Disease Therapy

New findings from University of Udine describe advances in Gaucher disease therapy

Published in Blood Weekly, July 12th, 2007

Fresh data on Gaucher disease are presented in the report "Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress." According to recent research published in the Journal of Cellular Physiology, "Gaucher disease (GD) is a lysosomal storage disorder, due to glucosylceramide (GlcCer) accumulation in several body tissues, which causes cellular failure by yet unidentified mechanisms. Several evidence indicates that GD pathogenesis is associated to an impairment in intracellular redox state."

"In fibroblast primary cultures, reactive oxygen species (ROS) levels and protein carbonyl content resulted...

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Source: Blood Weekly (2007-07-12)

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