Myelofibrosis Genetics
New findings in myelofibrosis genetics described from University of Kansas
Published in Blood Weekly, July 19th, 2007
Current study results from the report, "Expression of bone morphogenetic proteins and their receptors in the bone marrow megakaryocytes of GATA-1(low) Mice: a possible role in osteosclerosis," have been published. "The mechanism of osteosclerosis associated with myelofibrosis in megakaryocyte (MK)-related myeloproliferative disorders is largely unknown. However, growth factors released from the bone marrow cells, including from MKs, have been implicated in myelofibrosis, osteosclerosis, and angiogenesis," scientists in the United States report.
"GATA-1 is a transcription factor required for normal MK development. GATA-1 deficiency in mice (GATA-1(low)) leads to...
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Source: Blood Weekly (2007-07-19)
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