Leukemia Cell Biology
New leukemia cell biology research from University of Erlangen outlined
Published in Blood Weekly, August 2nd, 2007
New research, "A CD19-specific single-chain immunotoxin mediates potent apoptosis of B-lineage leukemic cells," is the subject of a report. "CD19 is a B-lineage-specific transmembrane signaling protein participating in the control of proliferation and differentiation. It is present at high surface density on chronic B-lymphocytic leukemia (B-CLL) cells and cells of other B-cell malignancies, and is a prime target for therapy with antibody-derived agents," researchers in Erlangen, Germany report.
"Many attempts have been made to target malignant cells via CD19, but to date none of these agents have received drug approval. Here we report the design of a monovalent...
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Source: Blood Weekly (2007-08-02)
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