Cancer

Research results from K.E. Corcoran and co-authors update knowledge of cancer

Published in Blood Weekly, August 2nd, 2007

"Stromal cell-derived factor-1 alpha (SDF-alpha) is a CXC chemokine that interacts with CXCR4 receptor. Tac1 encodes peptides belonging to the tachykinins, including substance P," researchers in the United States report.

"SDF-1 alpha, production is decreased in Tac1 knockdown breast cancer cells and is also reduced in these cancer cells following contact with bone marrow stroma when Tac1 expression is increased. Here, we report on the effects of relatively high and low SDF-1 alpha levels on Tac1 expression in nontumorigenic breast cells MCF12A. Reporter gene assays, Northern analyses, and ELISA for substance P showed increased Tac1 expression at 20 and 50 ng/mL SDF-1...

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Source: Blood Weekly (2007-08-02)

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