Chronic Myeloid Leukemia

New findings in chronic myeloid leukemia described from University of Bari

Published in Blood Weekly, August 2nd, 2007

"We carried out fluorescence in situ hybridization (FISH) studies on 18 Ph+ chronic myeloid leukemia (CML) cases with chromosome 22 genomic deletions with the Vysis BCR-ABL dual-color/dual-fusion probe (BCR-ABL DC/DF) to compare the hybridization patterns obtained with this approach to those obtained with the ''home brew'' BAC/PAC system," scientists in Bari, Italy report.

"Our results are the following: chromosome 22 microdeletions less than 400 kilobases (Kb) were not detected by the BCR DC/DF probe; FISH analysis with the BCR DC/DF probe in cases bearing chromosome 22 microdeletions ranging from 400 to 700 Kb produced a faint signal on the der(9); and the BCR-ABL...

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Source: Blood Weekly (2007-08-02)

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