Iron Deficiency

Studies in the area of iron deficiency reported from M. Sanchez and co-researchers

Published in Blood Weekly, August 2nd, 2007

According to a study from Heidelberg, Germany, "Hypoxia stimulates erythropoiesis, the major iron-utilization pathway. We report the discovery of a conserved, functional iron-responsive element (IRE) in the 5' untranslated region of the messenger RNA encoding endothelial PAS domain protein-1, EPAS1 (also called hypoxia- inducible factor-2a, HIF2a)."

"Via this IRE, iron regulatory protein binding controls EPAS1 mRNA translation in response to cellular iron availability. Our results uncover a regulatory link that permits feedback control between iron availability and the expression of a key transcription factor promoting iron utilization," wrote M. Sanchez and...

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Source: Blood Weekly (2007-08-02)

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