Thrombosis

Recent studies by L. Dou and co-authors add new data to thrombosis findings

Published in Blood Weekly, August 2nd, 2007

According to recent research from Marseille, France, "Endothelial dysfunction and oxidative stress are matters of concern in patients with chronic renal failure (CRF). Uremic solutes retained in these patients could be involved in these processes."

"Notably, the protein-bound uremic solute indoxyl sulfate induces endothelial dysfunction in vitro, and has shown pro-oxidant effects. To demonstrate that indoxyl sulfate is a potential mediator of oxidative stress in endothelial cells in vitro. Indoxyl sulfate-induced oxidative stress in human umbilical vein endothelial cells (HUVEC) was studied by measuring reactive oxygen specie (ROS) production by cytofluorimetry, by...

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Source: Blood Weekly (2007-08-02)

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