Published in Blood Weekly, August 2nd, 2007
"Notably, the protein-bound uremic solute indoxyl sulfate induces endothelial dysfunction in vitro, and has shown pro-oxidant effects. To demonstrate that indoxyl sulfate is a potential mediator of oxidative stress in endothelial cells in vitro. Indoxyl sulfate-induced oxidative stress in human umbilical vein endothelial cells (HUVEC) was studied by measuring reactive oxygen specie (ROS) production by cytofluorimetry, by...
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