Acute Myeloid Leukemia

Studies from INSERM further understanding of acute myeloid leukemia

Published in Blood Weekly, August 9th, 2007

According to recent research published in the journal Cellular Signalling, "Acute myeloid leukemia (APAL) cell lines treated by genotoxic agents or by Tumor Necrosis Factor alpha (TNF alpha) acquire potent cytotoxicity towards myeloid cells through activation of granzyme B (GrB)/perforin (PFN) system. Here we first extend this observation to another death receptor activator, Fas Ligand (FasL)."

"Moreover, we analyzed GrB induction signalling pathway in TNF alpha- and FasL-stimulated AML cells. The effects of TNF alpha and FasL on GrB expression were specifically mediated by p38MAPK (Mitogen-activated-protein-kinase) activation. Otherwise, TNF alpha and FasL...

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Source: Blood Weekly (2007-08-09)

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